Fig. 1

Proteomics analysis. A Dot heatmap of significantly regulated proteins across all contrasts. The proteins satisfy selection criteria: alpha = 0.001 and |logFC|> 1 at least in one of the eight contrasts (see Table 1), here shown as x-axis labels. All contrasts in this and the next plot are split into four groups: group I for comparison of C19 high PCT vs. C19 low PCT, group II for comparison of C19 groups vs. HSVE, group III for comparison of C19 groups vs. controls and group IV for comparison of HSVE group vs. controls. One can see that the strongest regulation (by the number of proteins with high |logFC|) is observed for HSVE vs. control (group IV). Regulation in a group of contrasts III (COVID-19 groups vs. control, contrasts 5–7 in Table 1) appears as following the regulation in group IV (contrast 8 in Table X2). Still, the extent of the regulation is different, as can be seen from the pattern of protein regulation in a group of contrasts II (COVID-19 groups vs. HSVE, contrasts 2–4 in Table 1). B Dot heatmap of significantly enriched REACTOME terms across all contrasts. Results of GSEA using REACTOME functional terms with FDR < 0.05 at least in one of the eight contrasts (see Table 1). All contrasts in the plot are split into four groups: group I for comparison of C19 high PCT vs. C19 low PCT, group II for the comparison of C19 groups vs. HSVE, group III for the comparison of C19 groups vs. controls and group IV for the comparison of HSVE group vs. controls