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Table 3 Cytokine and progranulin levels and ratios in our groups

From: The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation

 

N

Mean serum level (pg/mg)

Range (pg/ml)

Mean CSF level (pg/ml)

Range (pg/ml)

Ratio

Range

IL-6

 NC

11

2.6

0.0–9.4

3.2

0.5–9.7

1.23

0.0–26.8

 HSVE

10

12.7

0.0–57.35

315.5

1.77–552.9

24.84

0.0–57.35

 C19 total

18

92.5

0.75–552.4

37.0

0.68–552.1

0.4

0.02–5.09

 C19 lowpct

12

51.3

0.75–345.5

7.00

0.68–24.72

0.14

0.02–5.09

 C19 highpct

6

174.9

7.1–552.4

96.9

1.54–552.1

0.55

0.02–0.98

IL-16

 NC

11

206.1

165.3–275.8

45.2

39.3–57.6

0.22

0.16–0.3

 HSVE

5

253.2

209.8–316.6

115.7

73.8–18.8

0.46

0.31–0.53

 C19 total

18

358.9

109.7–775.8

53.3

44.7–74.8

0.15

0.09–0.52

 C19 lowpct

12

295.0

109.7–521.2

52.4

44.7–67.2

0.18

0.11–0.52

 C19 highpct

6

486.8

226.2–775.8

55.6

43.3–74.8

0.11

0.08–0.19

CXCL10

 NC

11

161.6

91.37–368.4

205.4

89.26–416.1

1.27

0.6–4.04

 HSVE

10

256.5

83.37–627.5

894.8

285.9–1087.3

3.49

1.56–13.04

 C19 total

18

405.2

32.77–1234.3

226.7

49.06–622.1

0.56

0.08–7.71

 C19 lowpct

12

301.8

32.77–765.7

178.0

13.91–622.1

0.59

0.08–7.71

 C19 highpct

6

612.1

57.92

324.0

49.83–565.1

0.53

0.2–0.98

PGRN

 NC

22

N.a

N.a

0.9963

0.49–2.09

n.a

n.a

 MHSVE

6

N.a

N.a

5.6717

1.04–9.81

n.a

n.a

 C19 total

23

N.a

N.a

1.675

0.67–3.04

n.a

n.a

 C19 lowpct

13

N.a

N.a

1678

0.67–3.04

n.a

n.a

 C19 highpct

10

N.a

N.a

1.671

07.5–2.22

n.a

n.a

  1. IL-6 = interleukin-6, IL-16 = interleukin-16, CXCL10 = C-X-C motif chemokine 10; n.a. = not available, PGRN = progranulin. NC = non-inflammatory, non-neurodegenerative controls