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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism

Fig. 7

Glycolysis is increased in Aβ-accumulating astrocytes. There are three main pathways for energy production in cells: glycolysis, the citric acid cycle + OXPHOS, and fatty acid β oxidation (A). Although LDH levels were increased at 7 day after Aβ exposure (B), lactate levels remained stable (C), suggesting that the astrocytes try to switch to glycolysis but are not successful. Seahorse analysis revealed that both glycolysis and glycolytic capacity of Aβ-exposed astrocytes were increased at day 7 and 7 + 6 (D, E, G, H). This increase was, however, no longer observed at 7d + 12d (F–H)

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Journal of Neuroinflammation

ISSN: 1742-2094