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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Cannabinoids modulate the microbiota–gut–brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels

Fig. 7

Bifidobacteriaceae, Ruminococcaceae, Lachnospiraceae, Bifidobacterium, Lachnospira, and Faecalibacterium are significantly enriched in colon of THC/SIV RMs. The taxonomy cluster (A) and heat map (B, I) of top 21 colon bacterial family (A, B) and genus (I) at 6 MPI in VEH/SIV and THC/SIV relative to uninfected control RMs. Dot plots (family) show relative abundance of Clostridiales_Family_XII_Incertae_Sedis (C), Clostridiales_Family_XIII_Incertae_Sedis (D), Bifidobacteriaceae (E), Ruminococcaceae (F), Lachnospiraceae (G) and Bacteriodaceae (H) in colon of VEH/SIV and THC/SIV relative to uninfected control RMs. Dot plots (genus) show relative abundance of Clostridiales_unclasiffied (J), Clostridiaceae_unclassified (K), Clostridiaceae_noname (L), Lachnospiraceae_unclassified (M), Bifidobacterium (N), Lachnospira (O), Faecalibacterium (P), Peptostreptococcaceae_noname (Q) Ruminococcaceae_unclassified (R), and Bacteriodes (S) in colon of VEH/SIV and THC/SIV relative to uninfected control RMs. CCCN–uninfected controls, VEHC6M–VEH/SIV 6 MPI, THCC6M–THC/SIV 6 MPI, MPI–months post-SIV infection. A p-value of < 0.05 was considered significant

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Journal of Neuroinflammation

ISSN: 1742-2094