Old age promotes retinal fibrosis in choroidal neovascularization through circulating fibrocytes and profibrotic macrophages

Table 2 Cytokine/chemokines production of BMDMs from young and aged mice with/without subretinal fibrosis

Cytokines	Groups	Control	Subretinal fibrosis	p value
CXCL10	Young	577.83 ± 44.05	135.99 ± 35.32	0.000
	Aged	321.68 ± 119.46	154.56 ± 36.34	0.044
uPAR	Young	44.94 ± 15.75	313.91 ± 80.79	0.001
	Aged	38.70 ± 14.06	330.79 ± 72.55	0.001
VEGF	Young	402.54 ± 147.91	377.01 ± 103.45	0.797
	Aged	324.79 ± 42.49	732.84 ± 188.64	0.029
Ang-2	Young	136.67 ± 71.45	170.83 ± 56.14	0.505
	Aged	112.36 ± 38.47	567.41 ± 96.99	0.045

Cytokine/growth factor values were normalized to total protein levels of the samples and expressed as pg/total protein. Mean ± SD, n = 4, Student t test

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