Fig. 3

Genetic deletion of Mac1 mitigates P + M-elicited neuronal damage, synaptic loss and phosphorylation (Ser129) of α-synuclein in mice. A Representative pictures of PSD-95 and Neu-N staining in WT and Mac1^−/− mice. B Quantification of Neu-N⁺ cells. C–E Quantification of optical density of PSD-95 staining. F Representative blots of PSD-95, Neu-N, TH, toal and phosphorylated (Ser129) α-synuclein in mice. G–K Quantification of the blots. n = 4–6; **p < 0.01 for comparison between Con & P + M groups; ^#p < 0.05, ^##p < 0.01 for comparison between WT-P + M & Mac1^−/−-P + M groups; Scale bar = 200 μm