Fig. 5

Genetic deletion of Mac1 mitigates P + M-elicited NLRP3 inflammasome activation in mice. A Representative blots of NLRP3, active caspase-1 and mature IL-1β in WT and Mac1^−/− mice. n = 6 B–D Quantification of the blots. E Contents of IL-1β in mice. F Representative images of double caspase-1 and Iba-1 fluorescence staining in P + M-injected WT and Mac1^−/− mice. n = 3. **p < 0.01 for comparison between Con & P + M groups; ^#p < 0.05, ^##p < 0.01 for comparison between WT-P + M & Mac1^−/−-P + M groups; Scale bar = 50 μm