Fig. 4
From: Depletion and activation of microglia impact metabolic connectivity of the mouse brain
Cellular allocation of FDG uptake in Grn−/− and WT mice. A, B %-FDG uptake per cell in the isolated neuron, astrocyte, and microglia fractions from Grn−/− and WT mice. Mean ± SEM of n = 2–5 animals. Two-way ANOVA with Bonferroni correction for multiple comparisons, Grn−/− neuron vs. WT neuron p = 0.0006. C–E Immunoblot expression of CD11b, glutamine synthetase and Actin, as a loading control, in Grn−/− vs. WT, n = 4 mice per group. Unpaired t test, CD11b p = 0.0044; GS p = 0.7753. F, G Relative proportions of brain FDG allocation accounting from neurons, astrocytes, and microglia