Table 1 Transcriptional changes in the cerebrum of TMEV- and mock-infected SJL and C57BL/6 mice (fold changes)
Gene symbol | Gene title | Strain strain | 4 dpi | 7 dpi | 14 dpi |
|---|---|---|---|---|---|
Pattern recognition receptors | |||||
Ddx58 (RIG-I) | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | SJL | 5.29 | 9.22 | 1.90 |
B6 | 6.92 | 7.00 | 1.87 | ||
Eif2ak2 (PKR) | Eukaryotic translation initiation factor 2-alpha kinase 4 | SJL | 6.18 | 11.35 | 2.21 |
B6 | 6.36 | 7.99 | 1.96 | ||
Ifih1 (MDA5) | Interferon induced with helicase C domain 1 | SJL | 4.28 | 9.25 | 1.94 |
B6 | 5.67 | 6.64 | 1.80 | ||
Tlr3 | Toll-like receptor 3 | SJL | 2.33 | 3.48 | 1.56 |
B6 | 2.82 | 2.72 | 1.30 | ||
Tlr7 | Toll-like receptor 7 | SJL | 2.39 | 3.98 | 1.54 |
B6 | 3.35 | 2.94 | 1.70 | ||
Interferon regulatory factors | |||||
Irf1 | Interferon regulatory factor 1 | SJL | 2.71 | 8.91 | 2.41 |
B6 | 2.96 | 5.05 | 1.72 | ||
Irf3 | Interferon regulatory factor 3 | SJL | 1.11 | 1.00 | 1.21 |
B6 | 1.13 | 1.08 | 1.12 | ||
Irf5 | Interferon regulatory factor 5 | SJL | 2.07 | 3.12 | 1.57 |
B6 | 2.77 | 2.55 | 1.48 | ||
Irf7 | Interferon regulatory factor 7 | SJL | 5.42 | 7.28 | 1.78 |
B6 | 4.77 | 4.87 | 1.26 | ||
Type I/II interferons | |||||
Ifna4 | Interferon alpha 4 | SJL | 3.70 | 1.24 | 0.89 |
B6 | 1.63 | 1.09 | 0.88 | ||
Ifnb1 | Interferon beta 1 | SJL | 4.23 | 1.47 | 0.85 |
B6 | 1.65 | 1.07 | 0.94 | ||
Ifng | Interferon gamma | SJL | 1.56 | 5.40 | 1.61 |
B6 | 1.53 | 2.71 | 1.51 | ||
Type I/II interferon receptors | |||||
Ifnar1 | interferon alpha/beta receptor 1 | SJL | 0.93 | 1.21 | 0.99 |
B6 | 1.13 | 1.01 | 0.93 | ||
Ifnar2 | interferon alpha/ beta/omega receptor 2 | SJL | 1.56 | 1.67 | 1.49 |
B6 | 1.54 | 1.43 | 1.09 | ||
Ifngr1 | Interferon gamma receptor 1 | SJL | 1.21 | 1.84 | 1.25 |
B6 | 1.58 | 1.49 | 1.27 | ||
Ifngr2 | Interferon gamma receptor 2 | SJL | 1.15 | 1.12 | 1.20 |
B6 | 1.00 | 1.13 | 1.00 | ||
Signal transducers | |||||
Irf9 | Interferon regulatory factor 9 | SJL | 6.06 | 7.33 | 2.75 |
B6 | 4.44 | 5.76 | 1.80 | ||
Jak1 | Janus kinase 1 | SJL | 0.72 | 1.22 | 0.81 |
B6 | 0.96 | 1.14 | 1.11 | ||
Socs1 | Suppressor of cytokine signaling 1 | SJL | 3.67 | 4.84 | 1.62 |
B6 | 2.35 | 3.72 | 1.29 | ||
Stat1 | Signal transducer and activator of transcription 1 | SJL | 8.56 | 14.23 | 3.90 |
B6 | 5.51 | 9.64 | 2.04 | ||
Stat2 | Signal transducer and activator of transcription 2 | SJL | 2.53 | 4.99 | 1.44 |
B6 | 3.63 | 4.48 | 1.25 | ||
Tyk2 | Tyrosine kinase 2 | SJL | 1.15 | 1.24 | 1.19 |
B6 | 1.31 | 1.10 | 1.02 | ||
Interferon-dependent antiviral effectors | |||||
Cd74 | CD74 antigen | SJL | 2.08 | 15.36 | 10.65 |
B6 | 2.79 | 6.51 | 3.97 | ||
Ddx60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | SJL | 8.80 | 15.53 | 2.99 |
B6 | 10.64 | 10.09 | 2.51 | ||
Ifi44 | Interferon-induced protein 44 | SJL | 6.91 | 10.78 | 2.48 |
B6 | 6.00 | 6.79 | 1.34 | ||
Ifi202b | Interferon activated gene 202B | SJL | 14.75 | 34.01 | 4.76 |
B6 | 0.74 | 0.86 | 0.67 | ||
Ifit1 (Isg56) | Interferon-induced protein with tetratricopeptide repeats 1 | SJL | 9.91 | 14.03 | 3.05 |
B6 | 7.23 | 9.25 | 1.62 | ||
Ifit3 (Isg60) | Interferon-induced protein with tetratricopeptide repeats 3 | SJL | 9.42 | 10.02 | 2.40 |
B6 | 5.95 | 6.35 | 1.41 | ||
Isg15 | ISG15 ubiquitin-like modifier | SJL | 9.27 | 9.32 | 2.38 |
B6 | 4.59 | 6.28 | 1.06 | ||
Mx1 | Myxovirus (influenza virus) resistance 1 | SJL | 3.96 | 5.63 | 1.29 |
B6 | 5.08 | 4.15 | 1.11 | ||
Mx2 | Myxovirus (influenza virus) resistance 2 | SJL | 8.56 | 8.62 | 2.40 |
B6 | 5.75 | 5.18 | 1.25 | ||
Oas1a | 2'-5' Oligoadenylate synthetase 1A | SJL | 4.43 | 6.08 | 1.92 |
B6 | 4.16 | 4.27 | 1.30 | ||
Oas1b | 2'-5' Oligoadenylate synthetase 1B | SJL | 8.56 | 10.08 | 2.82 |
B6 | 5.88 | 5.97 | 1.65 | ||
Oasl1 | 2'-5' Oligoadenylate synthetase-like 1 | SJL | 2.81 | 3.81 | 1.03 |
B6 | 3.79 | 3.15 | 1.08 | ||
Oasl2 | 2'-5' Oligoadenylate synthetase-like 2 | SJL | 7.66 | 10.94 | 2.64 |
B6 | 6.23 | 8.49 | 1.59 | ||
Rnasel | Ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) | SJL | 0.81 | 2.08 | 0.75 |
B6 | 1.29 | 1.37 | 1.14 | ||
Rtp4 | Receptor transporter protein 4 | SJL | 10.01 | 15.45 | 3.66 |
B6 | 7.07 | 8.70 | 1.91 | ||
Trim12a | Tripartite motif-containing 12A | SJL | 1.05 | 1.03 | 0.77 |
B6 | 4.79 | 5.09 | 2.31 | ||
Trim12c | Tripartite motif-containing 12C | SJL | 1.53 | 1.66 | 1.18 |
B6 | 4.61 | 4.68 | 1.96 | ||
Trim30a | Tripartite motif-containing 30A | SJL | 4.42 | 10.37 | 1.92 |
B6 | 7.28 | 7.19 | 2.06 | ||