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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Human umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT/GSK-3β/β-TrCP/Nrf2 axis

Fig. 2

Combined curcumin-hUC-MSC treatment decreased neuronal apoptosis. A Representative images of immunofluorescence analysis for neuronal apoptosis with whole brain tissue, scale bars = 600 μm. B, C Representative images (B) and quantification (C) of immunofluorescence analysis for neuronal apoptosis in the ischemic penumbra. The neuron-specific marker NeuN (green), and the apoptosis marker CC3 (red). Nuclei were stained with DAPI (blue). The white five-pointed star indicates the infarct core, scale bar, 20 μm. D Western blot and quantitative analysis of the expression of CC3 in the infarction region of the ipsilateral cerebral hemisphere. Cur curcumin, N = 5; N.S. no significant difference, *P < 0.05, **P < 0.01, ***P < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094