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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: A short peptide exerts neuroprotective effects on cerebral ischemia–reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis

Fig. 10

NP1 reduced IKKβ and inhibited NF-κB activation at 48 h after I/R (n = 3). A NP1 reduced expression of IKKβ at the mRNA level at 48 h after I/R injury in rats. B NP1 reduced expression of IKKβ at the protein level at 48 h after I/R injury in rats. C NP1 reduced phosphorylation levels of NF-κB p65 at 48 h after I/R injury in rats. D NP1 increased expression of total I-κB protein and reduced phosphorylation levels of I-κB at 48 h after I/R injury in rats. Data are presented as means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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Journal of Neuroinflammation

ISSN: 1742-2094