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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Exogenous monocyte myeloid-derived suppressor cells ameliorate immune imbalance, neuroinflammation and cognitive impairment in 5xFAD mice infected with Porphyromonas gingivalis

Fig. 5

Exogenous mMDSCs increased the proportion and immunosuppression of mMDSCs in 5xFAD mice infected with Pg. A Representative FACS plots of gating strategy for Gr1+ cells, MDSCs, mMDSCs, gMDSCs and IL-10-producing mMDSCs or gMDSCs. Statistical results of MDSCs proportions in BL (B) and SP (C). D Statistical results of Gr1+ cells proportions in BM. Statistical results of mMDSCs proportions in BL (E), SP (F) and BM (G). Statistical results of gMDSCs proportions in BL (H), SP (I) and BM (J). Statistical results of IL-10-producing mMDSCs proportions in BL (K) and BM (L). M Statistical results of IL-10-producing gMDSCs proportions in SP. Relative mRNA expression of Arg1 (N) and Nos2 (O) in SP detected by qRT-PCR. Relative mRNA expression of Arg1 (P) and Nos2 (Q) in BM detected by qRT-PCR. Data are presented as means ± SEM. * p < 0.05; ** p < 0.01; *** p < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094