Table 2 Partial correlation analysis between inflammatory cytokines and grey matter volume and metabolism
Inflammatory factors | Structural MRI | r/rho | FDR adjusted P value | FDG–PET | r/rho | FDR adjusted P value |
|---|---|---|---|---|---|---|
IL-2 | Left hippocampus | − 0.5153 | 0.0053 | Left superior temporal | − 0.6110 | 0.0300 |
|  | Left inferior frontal gyrus, opercular part | − 0.4482 | 0.0175 | Left superior temporal pole | − 0.5786 | 0.0435 |
|  | Left inferior frontal orbital | − 0.4100 | 0.0316 | Left amygdala | − 0.5703 | 0.0061 |
|  |  |  |  | Left inferior frontal gyrus, opercular part | − 0.5581 | 0.0133 |
|  |  |  |  | Left para-hippocampus | − 0.4930 | 0.0161 |
IL-12p70 | Left inferior frontal orbital | − 0.5769 | 0.0014 | Left middle temporal pole | − 0.5878 | 0.0035 |
|  | Left rectus | − 0.5317 | 0.0038 | Left superior temporal pole | − 0.5809 | 0.0008 |
|  | Left olfactory | − 0.5317 | 0.0038 | Left olfactory | − 0.5768 | 0.0218 |
|  | Left middle frontal orbital | − 0.5288 | 0.0041 | Left anterior cingulate | − 0.5228 | 0.0090 |
|  | Left superior frontal orbital | − 0.5098 | 0.0059 | Left inferior temporal | − 0.5055 | 0.0277 |
|  | Left medial frontal orbital | − 0.5054 | 0.0065 | Left medial frontal orbital | − 0.4691 | 0.0203 |
|  | Left superior medial frontal | − 0.5020 | 0.0069 | Left superior medial frontal | − 0.4647 | 0.0218 |
IL-17A | Left hippocampus | − 0.6302 | 0.0004 | Left inferior frontal gyrus, opercular part | − 0.6165 | 0.0357 |
|  | Left para-hippocampus | − 0.4900 | 0.0085 | Left amygdala | − 0.5820 | 0.0018 |
|  | Left inferior frontal gyrus, opercular part | − 0.4151 | 0.0293 | Left para-hippocampus | − 0.5335 | 0.0023 |
|  | Left inferior frontal orbital | − 0.4046 | 0.0342 | Left olfactory | − 0.5112 | 0.0201 |
sCD30/TNFRSF8 | ns |  |  | Right amygdala | − 0.5379 | 0.0264 |
|  |  |  |  | Right hippocampus | − 0.5325 | 0.0075 |
|  |  |  |  | Left amygdala | − 0.4860 | 0.0027 |
TNF-α | Left hippocampus | − 0.6471 | 0.0002 | Left amygdala | − 0.5622 | 0.0021 |
|  | Left para-hippocampus | − 0.5401 | 0.0032 | Left superior temporal pole | − 0.5544 | 0.0055 |
|  | Left insula | − 0.5162 | 0.0052 | Left anterior cingulate | − 0.5077 | 0.0090 |
|  | Left inferior frontal orbital | − 0.5055 | 0.0065 | Left olfactory | − 0.4928 | 0.0010 |
|  | Left superior medial frontal | − 0.5040 | 0.0066 | Left superior medial frontal | − 0.4913 | 0.0154 |
|  | Left inferior frontal gyrus, opercular part | − 0.4956 | 0.0077 | Right insula | − 0.4850 | 0.0267 |
|  | Left putamen | − 0.4879 | 0.0089 | Left para-hippocampus | − 0.4823 | 0.0022 |
|  | Right inferior frontal orbital | − 0.4837 | 0.0095 | Left medial frontal orbital | − 0.4499 | 0.0185 |