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Table 1 Overview on animals and key results of the cross-sectional preclinical study

From: [18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data

Mouse

model

Age (mo)

[18F]F-DED small animal PET (n)

[18F]F-DED small animal PET

(DVRHIP)

[18F]F-DED small animal PET

(DVRTHA)

[18F]GE-180 small animal PET (n)

[18F]florbetaben small animal PET (n)

 

PS2APP

5.9

7

1.09 ± 0.07

1.17 ± 0.06*

7

6

 
 

13.4

9

1.11 ± 0.05*

1.18 ± 0.07

6

8

 
 

19.5

8

1.20 ± 0.05**

1.25 ± 0.07**

5

8

 

Wild type

5.1

11

1.07 ± 0.03

1.09 ± 0.06

   
 

11.2

6

1.03 ± 0.07

1.08 ± 0.12

   
 

18.6

8

1.06 ± 0.06

1.08 ± 0.03

   
  1. Small-animal PET DVRs are shown for [18F]F-DED
  2. Significant differences in PS2APP mice vs. age-matched wild-type controls are indicated by *p < 0.5; **p < 0.001
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Journal of Neuroinflammation

ISSN: 1742-2094