Fig. 2

Protein–protein interaction networks and functional enrichment analysis of 17 differential targets. There are two major protein–protein interaction network modules, both of which are significantly associated with AD-related biological processes and pathological processes. The module 1 includes six differential targets (ADAM10, ADAMTS1, ADAMTS4, NDUFAF6, SPPL2A, TSPAN14), while six differential targets (CLU, FERMT2, PTK2B, SLC24A4, SORL1, TREM2) in module 2. In biological process, the module 1 genes are enriched in “integrin-mediated signaling pathway”; module 2 genes are enriched in processes including “glial cell proliferation”, “regulation of neurofibrillary tangle assembly” and “integrin-mediated signaling pathway”. Both module genes are enriched in AD-related pathological processes including “Alzheimer’s disease”, “Neurodegenerative disease” and “Amyloidosis”