Fig. 8

ICM reversed the impairment of neuronal activity and synaptic dysfunction in the hippocampus of SAE mice. A Representative images of immunofluorescence staining of c-Fos (red), DAPI (blue) and colocalization in the hippocampus, scale bar = 10 μm; B quantification of the number of c-Fos⁺ cells in the hippocampus among the four groups. (n = 3 mice/group). C Schematic representation of fEPSPs before (1) and after (2) HFS among the four groups. Horizontal calibration bars, 10 ms; vertical bars, 0.5 mV. D Time-dependent changes in the slope of fEPSPs before (1) and after (2) HFS in hippocampal slices among the four groups. E Quantification of fEPSP slopes evoked by HFS among the four groups. (n = 5–6 slices/group). Data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, ****P < 0.0001 vs. the indicated groups