Fig. 9From: HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathyThe schematic diagram illustrates that CLP induces increased secretion of HMGB1 and microglial activation, thus causing abnormal synaptic elimination and decreased theta oscillation. Abnormal theta oscillation reduces c-Fos+ cells and impairs LTP, ultimately leading to cognitive impairment in SAE miceBack to article page