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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: STING controls opioid-induced itch and chronic itch via spinal tank-binding kinase 1-dependent type I interferon response in mice

Fig. 4

The murine STING agonist DMXAA elevates spinal phosphorylation of TBK1 and IRF3 in dermatitis-induce chronic pruritus. A Experimental design to test the anti-pruritus effect of DMXAA in contact dermatitis model. B pre-treatment with DMXAA reduces DCP-induced scratching behaviors. n = 8 mice/group. C Single application of DMXAA on days 10 after DCP exposure reduced the established pruritus. n = 8 mice/group. D–H Western blot showed that two injections of DMXAA (i.p., 20 mg/kg) daily from day 3 to 4 after DCP exposure affect spinal TBK1 and IRF3 phosphorylation (but not expression) on day 5 after DCP intervention. n = 6 mice/group. Data are expressed as mean ± SD and analyzed by two-way ANOVA with Bonferroni post hoc test (B), unpaired two-tailed t test (C), and one-way ANOVA with Bonferroni post hoc test (E–H)

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Journal of Neuroinflammation

ISSN: 1742-2094