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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: STING controls opioid-induced itch and chronic itch via spinal tank-binding kinase 1-dependent type I interferon response in mice

Fig. 9

IFN-I activation reduces dry skin- and dermatitis-induce chronic itch in mice. A Experimental design for recombinant IFN-α and IFN-β therapy in AEW-induced chronic pruritus. B Pre-treatment with recombinant IFN-α and IFN-β reduces AEW-induced scratch bouts. C Experimental design for recombinant IFN-α and IFN-β therapy in DCP-induced chronic pruritus. D Pre-treatment with recombinant IFN-α and IFN-β reduces DCP-induced scratch bouts. n = 8 mice/group. Data are expressed as mean ± SD and analyzed by two-way ANOVA with Bonferroni post hoc test

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Journal of Neuroinflammation

ISSN: 1742-2094