Fig. 6

Intracisternal injection of E protein induced neuroinflammatory mediators in the cortex, hippocampus and olfactory bulb. A qRT-PCR analysis showed that intracisternal injection of E protein upregulated IL-1β, TNF-α, IL-6, CCL2, MMP2 and CSF1 in the cortex. B qRT-PCR analysis showed that intracisternal injection of E protein upregulated IL-1β, TNF-α, IL-6, CCL2, MMP2 and CSF1 in the hippocampus. C qRT-PCR analysis showed that intracisternal injection of E protein upregulated IL-1β, IL-6, and CCL2 in the olfactory bulb. n = 4; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; n.s., no significance; Student’s t test