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Table 2 Disease and demographic characteristics of study cohort (BA21, max n = 75)

From: Inflammatory panel cytokines are elevated in the neocortex of late-stage Alzheimer’s disease but not Lewy body dementias

 

Control

PDD

DLB

AD

p-value

Maximum n

18

22

21

14

 

Age at death, y

82.8 (1.2)

82.4 (1.0)

83.1 (1.6)

85.6 (1.5)

0.41

Female, %

9 (50.0)

11 (50.0)

11 (52.4)

8 (57.1)

0.98

Post-mortem intervala, h

41.5 (5.7)

37.3 (3.6)

44.6 (6.2)

39.0 (6.5)

0.78

Tissue pH

6.4 (0.1)

6.5 (0.1)

6.2 (0.1)

6.4 (0.1)

0.11

MMSE decline per yearb

NA

2.3 (0.3)

3.0 (0.5)

4.0 (1.2)

0.30

Predeath MMSEc

NA

10.9 (8.2)

12.2 (5.1)

8.4 (7.9)

0.52

Duration of dementiad, y

NA

3.7 (0.6)

6.4 (0.9)

9.7 (0.8)

< 0.001

Duration of parkinsonisme, y

NA

12.9 (1.3)

2.9 (0.7)

NA

< 0.001

Braak stagef, n

     

0–II

13

15

4

0

NA

III–IV

0

6

8

2

NA

V–VI

0

1

9

11

NA

NP scoreg

0.45 (0.2)

0.63 (0.1)

2.10 (0.2)*

2.92 (0.1)*

< 0.001

NFT scoreh

0.09 (0.1)

0.37 (0.1)

1.40 (0.2)*

2.83 (0.2)*†‡

< 0.001

LB scrorei

0

0.89 (0.2)*

1.75 (0.3)*

0.25 (0.1)

< 0.001

  1. All data expressed in mean (SEM) unless otherwise stated. PDD: Parkinson’s disease dementia; DLB: dementia with Lewy body; AD: Alzheimer’s disease; n: number; y: year; h: hour; MMSE: Mini-Mental State Examination; NA: not applicable
  2. aData on post-mortem interval were not available in 1 PDD case
  3. bData on predeath MMSE were not available in all controls, 2 PDD, 9 DLB and 1 AD cases
  4. cData on MMSE decline per year were not available in all controls, 1 PDD, 6 DLB and 2 AD cases
  5. dData on duration of dementia were not available in all controls, 1 PDD, 6 DLB and 1 AD cases
  6. eData on duration of parkinsonism symptoms were not available in all controls, 1 PDD, 7 DLB and 1 AD cases
  7. fData on Braak stage were not available in 5 controls and 1 AD case
  8. gData on NP score were not available in 2 controls, 3 PDD and 1 AD case
  9. hData on NFT score were not available in 2 controls and 1 AD case
  10. iData on LB score were not available in 7 controls, 1 DLB and 2 AD cases
  11. Dunn–Bonferroni post hoc tests correction was performed following a significant Kruskal–Wallis ANOVA), where significant differences from *Control, PDD and DLB were indicated accordingly