Fig. 3

CD4⁺ T cells in PBMCs by flow cytometry in 3- and 12-month-old male and female APP/PS1 mice and WT littermates. The proportion of Th1, Th2, Th17, and Treg cells was determined. A Proportion of Th1, Th2, and Th17 in male mice. B Proportion of Th1, Th2, and Th17 in female mice. C Proportion of Tregs. (Student’s t test. *P < 0.05, **P < 0.01, ***P<0.001, and ****P < 0.0001 compared to the WT group) (MT: male APP/PS1 group; MW: male WT group; FT: female APP/PS1 group; FW: female WT group; 3 M: 3-month-old; 12 M: 12-month-old)