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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Inhibition of discoidin domain receptor (DDR)-1 with nilotinib alters CSF miRNAs and is associated with reduced inflammation and vascular fibrosis in Alzheimer’s disease

Fig. 5

miRNAs that target autophagy and dopamine metabolism are significantly altered between placebo and nilotinib. A total of 17 microRNAs (1.6%) were significantly different between the placebo and nilotinib groups, accounting for both treatment and time. Ingenuity Pathway Analysis of microRNA matched associated mRNAs or targets that are experimentally validated from TarBase, miRecords, as well as highly predicted miRNA–mRNA interactions from TargetScan and revealed that 14 of these microRNAs are associated with genes that control autophagy and dopamine metabolism. N = 11 placebo, n = 12 nilotinib

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Journal of Neuroinflammation

ISSN: 1742-2094