Table 1 Statistical comparison of glial marker phenotypes in organotypic slices from 1.5-month-old and 7-month-old wild-type (B6SJL) and 5xFAD mice under various treatments (Fig. 1)

Microglia: Iba1^High CD68^High

 1.5 mo vs 7 mo B6SJL

p < 0.0001

p < 0.0001

p = 0.0002

p = 0.0016

 1.5 mo vs 7 mo 5xFAD

p < 0.0001

p < 0.0001

p < 0.0001

p < 0.0001

 1.5 mo B6SJL Control vs N-Aβcore

p = 0.9996

p = 0.7463

 1.5 mo 5xFAD Control vs N-Aβcore

p = 0.4282

p = 0.7463

 7 mo B6SJL Control vs N-Aβcore

p = 0.0296

p = 0.3023

 7 mo 5xFAD Control vs N-Aβcore

p = 0.1138

p = 0.4216

Astrocytes: GFAP^High

 1.5 mo vs 7 mo B6SJL

p = 0.9632

p = 0.9996

p = 0.0946

p = 0.9997

 1.5 mo vs 7 mo 5xFAD

p = 0.0003

p = 0.0124

p < 0.0001

p = 0.0620

 1.5 mo B6SJL Control vs N-Aβcore

p = 0.9513

p = 0.9997

 1.5 mo 5xFAD Control vs N-Aβcore

p = 0.9940

p = 0.0339

 7 mo B6SJL Control vs N-Aβcore

p = 0.3343

p = 0.1082

 7 mo 5xFAD Control vs N-Aβcore

p = 0.3853

p < 0.0001