Fig. 3
From: Analysis of the microglia transcriptome across the human lifespan using single cell RNA sequencing
Transcriptional landscape of microglia at distinct developmental ages. A Hierarchal clustering of microglia at each age according to Jaccard similarity coefficient score which is represented by a color gradient, yellow (highest similarity) and dark blue (lowest similarity). B PHATE visualization for ex vivo human microglia by age. C Dot plot depicting the most affected biological processes of the top 100 highly variable genes for each age. The circle size indicates the number of genes present in each biological process. Statistical significance of terms is represented by color gradient, p-value of all terms is < 0.05. D, E Heatmap showing expression of top 25 highly variable genes whose expression incrementally decreased D or increased E with age. Red and blue color indicate up and down regulation of genes, respectively