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Table 2 Validated serum miRNA differentially expressed between patients achieving NEDA-3 and EDA-3 at 2 years

From: miRNA 548a-3p as biomarker of NEDA-3 at 2 years in multiple sclerosis patients treated with fingolimod

miRNA

Discovery cohort (n = 31)

Validation cohort (n = 22)

Mean expression

Mean expression

NEDA-3

EDA-3

Adjusted p value*

NEDA-3

EDA-3

Adjusted p value*

Hsa-mir-487b.3p

− 8.540

− 9.691

< 0.001

− 6.404

− 7.354

0.135

Hsa-mir-380.3p

− 10.808

− 11.467

0.008

− 9.573

− 9.225

0.761

Hsa-mir-376b.3p

− 7.446

− 8.125

0.011

− 6.670

− 7.025

0.348

Hsa-mir-548a-3p

− 7.223

− 8.176

0.044

− 5.585

− 7.199

0.031

Hsa-mir-301b

− 8.375

− 8.499

0.024

− 7.378

− 7.550

0.252

  1. Top 5 miRNA expressed in both cohorts
  2. miRNA microRNA, MS multiple sclerosis
  3. *Adjusted p value from proportional odds model adjusting for age, sex and EDSS at baseline
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Journal of Neuroinflammation

ISSN: 1742-2094