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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: B cell treatment promotes a neuroprotective microenvironment after traumatic brain injury through reciprocal immunomodulation with infiltrating peripheral myeloid cells

Fig. 2

Multiplexed flow cytometry identification of cell populations in the CCI microenvironment. A Gating strategy for identifying resident and infiltrating immune cells after CCI. B Relative proportions of resident and infiltrating immune cells in the injured brain. In addition to the CNS-resident microglia, most infiltrating leukocytes are also of myeloid origin. Example shown at 96 h post-injury. C Immune cell populations in brain tissue from injured and sham-injured ipsilateral and contralateral hemispheres were analyzed. Gated populations were overlayed to show differential expression of CD45 and CD11b. Exogenous CD45hi CD11b− B cells can be found in treated injured and sham-injured animals (open arrows). A population of CD206+ monocytes/macrophages appeared distinctly enriched in the injured brain, particularly in animals treated with B cells (arrow)

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Journal of Neuroinflammation

ISSN: 1742-2094