Fig. 2
From: Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes
Glial cells show a distinct but sustained response after BDL compared to sham controls. A–H Volcano plots and heatmaps showing microglial (A–D) and astrocytic (E–H) gene expression changes 14 days (A, B, E, F) and 28 days (C, D, G, H) after BDL. In volcano plots (A, C, E, G), dotted lines indicate adjusted p-value (y-axis) and log2FC (x-axis) cut-offs for differential expression (red: DEG; green: failed p-value cut-off; blue: failed |log2FC| cut-off; gray: failed both cut-offs). Selected genes are manually labeled. Heatmaps (B, D, F, H) detail the top 25 DEGs ranked on |log2FC|. I Venn diagram showing overlapping DEGs based on cell type and time after induction