Fig. 4
From: Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes
Glial gene expression is enriched for inflammatory signaling. A, B, E, F Dot plots featuring the top 10 enriched biological pathways in BDL microglia after (A) 14 or (B) 28 days and astrocytes after (E) 14 and (F) 28 days. Biological pathways are ordered according to the ratio of the input DEG set annotated in the respective GO terms (geneRatio). Dot color corresponds to the adjusted p-value and dot size corresponds to the number of DEGs annotated in the respective GO term. C, D, G, H IPA analysis with identified upstream regulators of microglial signaling 14 (C) and 28 days (D) after BDL induction and of astrocytic signaling 14 (G) and 28 days (H) after BDL induction. Upstream regulators are ranked based on z-score. Bars represent z-score (orange: activation; blue: inhibition) and dots represent − log10 (P-value). Dotted lines indicate the p-value cut-off (p < 0.05) and dashed lines indicate the z-score cut-off (|z-score| > 2)