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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: GPR43 stimulation on TCRαβ+ intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity

Fig. 4

T-cells accumulate in the colonic intraepithelial compartment prior CNS infiltration. A Colonic IEL were isolated from EAE mice at indicated time points and the frequency of CD19+ B-cells, TCRγδ+ and total TCRαβ+ T-cells was analysed. B, C Colonic IEL and MNCs from CNS were isolated from EAE mice at indicated time points and the absolute number of B T-cell subsets CD4+, CD8αα+ and CD8αβ+ TCRαβ and C CXCR3 expressing T-cells was determined. D Percentage of CD4+, CD8αα+ and CD8αβ+ TCRαβ T-cells expressing CD103, α4β7 and CCR9. A–D Data were obtained from 6 to 12 mice per group. Values represent the mean ± SD. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001 by One-way ANOVA followed by Dunnett’s post-hoc test comparing frequencies of each cell type at different time points with the control condition (0 dpi)

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Journal of Neuroinflammation

ISSN: 1742-2094