Skip to main content
Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: GPR43 stimulation on TCRαβ+ intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity

Fig. 7

Propionate attenuates CXCL11-mediated migration of IEL TCRαβ+ T-cells. A The ability of IEL to migrate towards increasing concentrations of propionate was determined in transwell assay. Values represent mean ± SEM from 5 to 7 mice per group. B, C IEL were isolated from WT mice, stimulated with 100 μM propionate for 1 h and then the migration of TCRαβ+ T-cell subsets in response to 300 ng/mL CXCL11 was determined in transwell assay. Values are the number of TCRαβ+ T-cells on the bottom chamber normalised to the control condition (non-treated). Data were obtained from 7 to 10 mice per group. Each symbol represents data obtained from an individual mouse. Mean ± SEM are indicated. (A-C) *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001 compared with control condition by one-way ANOVA followed by the Dunnet's post-test

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094