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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia/reperfusion injury

Fig. 5

LCN2 induces NLRP3 inflammasome activation and subsequent pyroptosis in astrocytes. a Co-IF staining of GFAP with NLRP3, ASC and caspase-1. Scale bar = 20 μm. b WB analysis of LCN2, 24p3R, NLRP3, ASC, pro-caspase-1, cleaved caspase-1, pro-IL-1β, mature IL-1β and mature IL-18 in the penumbra region. Data are mean ± SD; n = 5 per group; ***P < 0.001 vs. corresponding sham-operated group; ###P < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094