Fig. 7
LCN2 mediates astrocyte pyroptosis by NLRP3 inflammasome activation via binding to 24p3R. a, b The efficacy of Nig in inducing NLRP3 inflammasome activation was evaluated by WB. n = 3 per group; ***P < 0.001, **P < 0.01; *P < 0.05 vs. sham-operated group; ###P < 0.001. c, d WB analysis of NLRP3, ASC, pro-caspase-1, cleaved caspase-1, GSDMD-FL, GSDMDNterm, pro-IL-1β, mature IL-1β and mature IL-18. n = 5 per group; ***P < 0.001, **P < 0.01 vs. sham-operated group; ###P < 0.001; $$$P < 0.001. Data are mean ± SD