Fig. 6

Impact of ligature-induced periodontal disease microbiome on β-amyloid phagocytic capacity of microglial cells. A Percentage of β-Amyloid 488 Fluor⁺ microglial cells stimulated with different MOIs of 10-day-old ligature-induced PD-associated microbiome for 24 h. (Experiments in triplicates, mean ± SEM, ANOVA, *p < 0.05, **p < 0.01, ****p < 0.0001 all comparisons were made to unstimulated microglial cells represented by the grey bar). B Levels of mRNA expression of mFPR2, class A scavenger receptor MSR1, and Class B scavenger receptor CD36 in microglial cells stimulated with MOI = 20 of 10-day-old ligature-induced PD-associated microbiome for 24 h. (Experiments in duplicate, mean ± SEM, Unpaired t test, *p < 0.05)