Fig. 8
From: Microglial cell response to experimental periodontal disease
Schematic diagram of TLR2 and TLR9 activation and microglial expression of pro-inflammatory cytokines and macrophage scavenger receptor1 (MSR1). TLR2 and TLR9 on microglia upon activation by microbiome associated with periodontal disease activate NF-κB. The subsequent activation of NF-κB increases the transcription of the pro-inflammatory cytokines and MSR1. In addition, the MSR1 expressed by activated microglia mediates cell phagocytosis of Aβ42