Fig. 5

The gut microbiota from ARDS/CAP patients induces behavioral disorders in mice. a Typical movement trajectories of mice receiving the faecal microbiota from ARDS/CAP patients (ARDS-R) or normal control subjects (CTRL-R) in the open field test (OFT). b–d The percentages of (b) distance and (c) time in the central area and (d) total distance in the OFT. e The escape latency of ARDS-R and CTRL-R mice during training in the Morris water maze (MWM). f Typical swimming trajectories of CTRL-R and ARDS-R mice during testing in the MWM. g–i The platform frequency (g) and the percentage of distance (h) and time (i) in goal area of CTRL-R and ARDS-R mice during testing in the MWM. j, k The spontaneous alternation (j) and total alternation of CTRL-R and ARDS-R mice in the Y-maze test. The statistic difference in the change of the escape latency between two groups was analyzed via a repeated measure ANOVA. The statistic difference of various indicators between two groups was evaluated by two-tailed unpaired student’s T test and a statistically significant was defined when p < 0.05. Significant level: *p < 0.05; **p < 0.01