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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Organotypic hippocampal culture model reveals differential responses to highly similar Zika virus isolates

Fig. 5

Different effects of PE243 or SPH2015 infection in the OHC transcriptome. A Upset plot representing DEGs by OHC infected with PE243 or SPH2015 16 h p.i.. Genes with Fold Change > 1.2 and P < 0.05 were considered differentially expressed. B and C Main biological processes predicted as activated or inhibited by the software IPA based on differentially expressed genes identified after the infection with PE243 (B) or SPH2015 (C). Filled shapes: in red = activated genes; in green = inhibited genes; in orange = predicted activated process; in blue = predicted inhibited process. Dashed lines: in orange = activation; in blue = inhibition; yellow = inconsistent; arrow shape = induction; T shape = suppression

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