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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Chronic social defeat alters brain vascular-associated cell gene expression patterns leading to vascular dysfunction and immune system activation

Fig. 2

Magnetic bead isolation in mice in HC and CSD conditions enriches for BVACs. a Key steps in the neurovascular cell isolation method. b UMAP of 12,744 cells following QC and integration from all CSD and HC samples, color-coded based on cell identification. c Heatmap of signature gene expression compared to all other clusters for neurovascular unit cell types that comprise the key brain barriers (i.e., BBB). Increased expression is colored red, and decreased expression is colored blue. QC quality control; UMAP uniform manifold approximation and projection; BBB  blood brain barrier; EC endothelial cell; IEG immediate-early gene; SMC smooth muscle cell; OPC oligodendrocyte precursor cell; CapEC capillary endothelial cell; MG microglia; ChPlex  choroid plexus; aEC arterial endothelial cell; AC astrocyte; vEC venous endothelial cell; BAM border-associated macrophage

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Journal of Neuroinflammation

ISSN: 1742-2094