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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Chronic social defeat alters brain vascular-associated cell gene expression patterns leading to vascular dysfunction and immune system activation

Fig. 4

Pathway enrichment analysis reveals vascular dysfunction and immune system activation following CSD. a, b Analysis of differentially expressed (DE) genes (CSD vs. HC) in Reactome and Gene Ontology: Biological Processes (GO: BP) identity key upregulated (a) and downregulated (b) pathways. Only a subset of significant (FDR < 0.05) pathways is shown. c–e Chord diagrams showing LAMININ (c), VEGF (d), and TNF (e) cell–cell communication networks for HC and CSD inferred from CellChat. f, g Bubble plots comparing inferred ligand-receptor interactions within the VEGF network between HC (f) and CSD (g) for each cell type calculated from CellChat. GO: BP  Gene Ontology: Biological Processes; FDR false discovery rate; SHR steroid hormone receptor; EC endothelial cell; SMC smooth muscle cell; OPC oligodendrocyte precursor cell; VEGF vascular endothelial growth factor; TNF tumor necrosis factor; HC home cage; CSD chronic social defeat

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Journal of Neuroinflammation

ISSN: 1742-2094