Fig. 3
From: A role for P-selectin and complement in the pathological sequelae of germinal matrix hemorrhage
Effect of P-selectin targeted complement inhibition on P-selectin expression, microgliosis and complement deposition in GMH mice. P14 brains sections were stained by immunofluorescence microscopy for P-selectin in 3 specific brain regions and expression quantified: a ipsilateral periventricular region, b ipsilateral hippocampus, and c ipsilateral white matter (corpus callosum). One-way ANOVA with Kruskal–Wallis correction (for non-parametric distribution) and Dunn’s multiple comparison. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Error bars = Median with interquartile range. Following immunofluorescence microscopy, C3 deposition (d) and microgliosis (e) was quantified in periventricular region of brains from indicated experimental groups. One-way ANOVA with Turkey’s correction for multiple comparisons. ****p < 0.0001. Error bars = mean ± SEM. f 63 × representative images of Iba1 (teal) and C3 (red) within periventricular region of vehicle and 2.3Psel-Crry treated GMH mice