Fig. 5.
From: A role for P-selectin and complement in the pathological sequelae of germinal matrix hemorrhage
2.12Psel-Crry, but not 2.3Psel-Crry, has anti-coagulative properties. Compared to treatment of GMH mice with 2.3Psel-Crry or PBS, treatment with 2.12Psel-Crry increases bleeding time (a) and inhibits heterotypic platelet–leukocyte aggregation (b, c). Heterotypic platelet interactions with neutrophils and monocytes quantified by CD41 + CD62P + CD11b + Ly6G + populations and CD41 + CD62P + CD11b + Ly6C + populations via flow cytometry for each experimental group. Unpaired Student’s t test. ** p < 0.01. Error bars = mean ± SEM. For (a), one-way ANOVA with Turkey’s correction. **p < 0.01, ***p < 0.001, ****p < 0.0001. Error bars = mean ± SEM