Fig. 3

Reversal of EAU-induced changes in gene expression and inflammatory responses by PRG. A Venn diagram showing the interaction (up) of upregulated EAU-DEGs and downregulated PRG-DEGs and that (down) of downregulated EAU-DEGs and upregulated PRG-DEGs in all cells. The black arrows indicate down (up) or upregulated (down) rescue-DEGs. B Representative GO biological process and pathways enriched in downregulated rescue-DEGs in all cells. C Representative GO biological process and pathways enriched in upregulated rescue-DEGs in all cells. D Rose diagram showing the number of up and downregulated rescue-DEGs among all immune cell types. E Bar chart showing the frequencies of the top 15 rescue-DEGs observed across all immune cell types. F Bar chart showing the ratio of rescue-DEGs to EAU-DEGs in each immune cell type. G Volcano plot showing the up and downregulated rescue-DEGs in CD8 + T cells. H Representative GO biological process and pathways enriched in downregulated rescue-DEGs in B cells. I Dot plot showing the relative changes in cell ratios of BC subsets across the three groups. The numbers on the right indicate the Log2FC values of the cell ratios (EAU/Naïve and PRG/EAU). J Venn diagram showing the interaction of downregulated rescue-DEGs in BC subsets