Fig. 5
From: Progesterone attenuates Th17-cell pathogenicity in autoimmune uveitis via Id2/Pim1 axis
Inversion of EAU-induced increase in the proportion and functional genes of Th17 by PRG. A Venn diagram showing the interaction of Th17 and Treg downregulated rescue-DEGs. B The heatmap showing the relative levels of 13 genes in Th17 and Treg among three groups. C The heatmap showing the relative levels of 13 genes among CD4 + TC subsets. D Violin plot showing the expression of selected genes in Th17 cells among three groups. E Ridge plots showing the gene set scores of the “rescue target genes” of Id2 (left) and Fos (right) in CD4 + TC subsets among three groups. F Representative GO biological process and pathways enriched in “rescue target genes” of Id2. G Representative GO biological process and pathways enriched in “rescue target genes” of Fos. The flow cytometry histograms (left) and column charts (right) showing the percentage of CD4 + IL-17A + Th17 cells (H), and the level of Pim1 (I) and Id2 (J) in Th17 cells among three groups (n = 5/group). Significance in H–J was calculated using one-way ANOVA test; **P < 0.01, ***P < 0.001, ****P < 0.0001