Fig. 3

OLT1177 reduces the levels of α-synuclein in the ventral midbrain after MPTP-subacute administration. a Representative immunoblotting showing the levels of monomeric and oligomeric forms of α-synuclein in the different groups. Mice were treated with 200 mg/kg of OLT1177 (OLT) for 6 days. Saline was used as vehicle. β-actin was used as loading control. Molecular weight (kDa) is marked on the right side. b and c Quantification of monomeric (b) and oligomeric (c) forms of α-synuclein. N = 4 for Sham + Saline and N = 5 for MPTP + Saline and MPTP + OLT. One-way ANOVA with Tukey’s post hoc correction was used to analyze differences between groups. *p < 0.05 and **p < 0.01