Fig. 4

OLT1177 modulates the dynamics of pro-inflammatory cytokines in the brain after MPTP-acute administration. a–d Brain levels of IL-1β (a and b) and IL-18 (c and d) in the striatum (St) and ventral midbrain (VM) 4 days after MPTP administration. e–h Brain levels of IL-6 (e and f) and IL-17A (g and h) 7 days after MPTP administration. Mice were treated with 200 mg/kg of OLT1177 (OLT) once each day starting one hour before MPTP administration. Saline was used as vehicle. Data are represented as mean ± SEM. N = 4 per group for a–d and N = 5 per groups for e–h. One-way ANOVA with Tukey’s post hoc correction was used to analyze differences between groups. *p < 0.05, **p < 0.01, and ***p < 0.001