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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Ambient RNAs removal of cortex-specific snRNA-seq reveals Apoe+ microglia/macrophage after deeper cerebral hypoperfusion in mice

Fig. 8

Differentially genes expressed analysis of MG/Immu between the BCAS and sham groups. A MDS (Multidimensional Scaling) plots show the separation MG/Immu subgroups between the BCAS and sham groups. MG1, microglia 1; MG2, microglia 2; Apoe+ MG/Mac: Apoe+ microglia/macrophage; Mac2: macrophage; DC, dendritic cell; Other, other cells. B Dot plots show the gene set enrichment analysis (GSEA) of up- and down- regulated functional pathways of three microglia subsets in the BCAS group. C GSEA plot shows the positive enrichment of the “response to interferon-β” pathway of MG2 in the BCAS groups. D GSEA plot shows the positive enrichment of the “defense response” pathway of MG1 in the BCAS groups. E t-SNE plots show the enrichment of MG/Immu subgroup in our snRNA-seq data for marker genes of SAMC (GSE189432) by using irGSEA analysis with the AUcell algorithm. F t-SNE plots show the expression of Lgals3 and Spp1 in different MG/Immu subsets between the sham and BCAS groups. G Dot plots show the average expression specific genes in different MG/Immu subsets

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Journal of Neuroinflammation

ISSN: 1742-2094