Fig. 1

SAFit2 reduces paclitaxel-induced mechanical hypersensitivity. A Schematic illustration of the animal treatment: neuropathic pain was induced with a multiple low-dose paclitaxel model, including four intraperitoneal injections with 2 mg/kg paclitaxel on day zero, two, four and six. Afterwards, the animals were treated with 10 mg/kg SAFit2 intraperitoneally from day five to ten two times daily. At day twelve, the mice were killed and DRGs and spinal cord samples collected. B Baseline measurements were performed on two different days before paclitaxel treatment. The mechanical pain threshold was assessed over 12 days every second day and the behavioral readout within the SAFit2 treatment was recorded between the SAFit2 treatments, approximately three hours after the first dose of SAFi2. The data represent the mean ± SEM from 13–14 mice per group. ***p < 0.001 two-way ANOVA with Bonferroni´s post hoc test. Pac paclitaxel, DRGs dorsal root ganglia, PWL paw withdrawal latency, SAFit2 selective antagonist of FKBP51 by induced fit 2