Fig. 2

Neuronal stress and ROS marker expression in DRGs and spinal cord. After 12 days, the expression of neuronal stress markers (A–C) and ROS markers (D–G) was assessed via qPCR. The expression of vehicle and SAFit2-treated animals were normalized to the expression of naïve animals. The data represent the mean ± SEM from 3–4 mice per group, measured in technical triplicates, respectively. * p < 0.05, ** p < 0.01, *** p < 0.001 one-way ANOVA with Tukey´s multiple comparison test per tissue. DRGs dorsal root ganglia, SC spinal cord, SAFit2 selective antagonist of FKBP51 by induced fit 2, ROS reactive oxygen species, ATF3 activating transcription factor 3, MMP9 matrix metallopeptidase 9, XDH xanthine dehydrogenase, NOX2/4 NADPH oxidase 2/4, iNOS inducible nitric oxide synthase