Fig. 3

Increase of anti-inflammatory cytokines and decrease of pain-mediating chemokines in neuronal tissue of SAFit2-treated animals. After 12 days, DRGs and spinal cord samples were homogenized and analyzed using a multiplex immunoassay including a panel of 26 cytokines and chemokines. This figure displays a section of significantly altered cytokines and chemokines in the DRGs (A–G) and spinal cord (H, I) after vehicle and SAFit2 treatment. The data represent the mean ± SEM from 5 mice per group. The raw data were related to the total protein amount of the sample. * p < 0.05, ** p < 0.01, *** p < 0.001 Student’s t-test with Welch’s correction. SAFit2 selective antagonist of FKBP51 by induced fit 2, DRGs dorsal root ganglia, SC spinal cord, IL interleukin, CCL C–C motif ligand, CXCL 10 C-X-C ligand 10