Fig. 1

CSDS decreases the expression of CD200 protein in DG. A Time-line of experimental procedures and schematic representation of chronic social defeat stress. SIT, social interaction test; SPT, sucrose preference test; FST, force swimming test; TST, tail suspension test. B Typical heatmap of SIT in control, susceptible and resilient mice. C Social interaction ratio in control and stressed mice. The data showed ratio < 1 in susceptible mice and > 1 in resilient mice (n = 11–12 per group, one-way ANOVA with Fisher’s LSD test). D Social interaction time in no target and target zone in control, susceptible and resilient mice following CSDS (n = 11–12 per group, two-way ANOVA with Fisher’s LSD test). E Immobility time in TST in control, susceptible and resilient mice (n = 12–16 per group, one-way ANOVA with Fisher’s LSD test). F Sucrose preference in control, susceptible and resilient mice (n = 11–12 per group, one-way ANOVA with Fisher’s LSD test). G Protein expression of CD200 in the DG region after CSDS (n = 5–8 per group, one-way ANOVA with Fisher’s LSD test). Data are expressed as mean ± SEM. **P < 0.01; ***P < 0.001. CON, control; SUS, susceptible; RES, resilient. See Additional file 1: Table S2 for detailed statistical information